Seed Grant Showcase Companies


Have you felt your laptop overheat while running power-hungry applications? You are definitely not alone. The clock rate and power density of processors in our electronics have hit a plateau, now limited by inefficient heat removal methods. In fact, in the words of one senior engineer interviewed at a large PC OEM, “one of the largest difficulties [OEMs] encounter in R&D is heat dissipation.” It should be no surprise that 55% of electronic failures are linked to heat!

NanoSink is revolutionizing the $10.7 billion market for thermal management in electronics by applying nanoscale solutions for heat dissipation. NanoSink utilizes metal sheets with macroscopic surface area and nanoscale thickness as a replacement for common heatsink components. While the dimensions of these fins have historically made it impossible to hold structural integrity, our corrugated structures optimize the efficiency of passive heat sinks. This results in more power, less space and less weight.

Inventors: John Bridstrup, Alexander David, Pavel Gurevich

For Inquires Please Contact:

 


Group K Diagnostics has developed a paper microfluidic platform diagnostic that can deliver quantitative results in 20 minutes or less.  We replace traditional laboratory systems and tests with an in-office, cost-effective diagnostic that allows providers to have actionable results within a visit. Our first offering is in liver function testing, with a clinical trial set to start at PennMed this fall.  We have over 60 other tests in our pipeline.

Inventor(s): Brianna Wronko

Website: www.groupkdiagnostics.com

For Inquiries Please Contact : Brianna Wronko at brianna@groupkdiagnostics.com or 1-201-450-8785

 


The Bone-on-a-chip is a small device containing patient-specific three-dimensional bone microstructure (obtained through high-resolution MRI or CT) and cells that emulates bone microenvironment and function in vitro. This device will serve as a non-invasive and inexpensive alternative to traditional approaches of studying the efficacy of drug treatment on bones through animal testing and clinical trials. The device will contain a porous bone microstructure fabricated through image-based patient-specific 3D printing using biocompatible material such as polycaprolactone (PCL), hydroxyapatite, collagen, etc., which will eventually be replaced by functional bone by inoculating the graft with mesenchymal stem cells and growth medium. Using inlets and outlets in the chip, the user will be able to flow fluid through the device, from blood to a newly developed drug. Through integrated electronic sensors the chip will also be able to undergo mechanical, imaging-based, and histological testing to determine the integrity of the bone after treatment.

Inventors: Rohit Shinde, Arbab Khalid, Abu-Bakr Ahmed, Sara Pennacchi, Matthew Peng, and Chamith Rajapakse

For Inquires Please Contact: Rohit Shinde (rohits@seas.upenn.edu) or Chamith Rajapakse (chamith@mail.med.upenn.edu)

 


Amsterdam Fluidics encapsulates cancer drugs so that they only they only target cancer cells — not healthy ones. This eliminates side effects of chemotherapy like hair loss, liver damage and organ failure. Current encapsulation methods are highly inefficient and inaccessible, but through implementing nanotechnology microfluidics, Amsterdam Fluidics encapsulates cheaper and faster. This makes targeted therapies in cancer and other drugs available to the people who need them. By creating an entire encapsulation facility for pharmaceutical companies on a single chip, Amsterdam Fluidics revolutionizes drug manufacturing and access on a worldwide scale.

Inventors: Niyathi Chakrapani, B.S. Candidate, Anirudh Kaushik, M.S.E., Sungwook Hwang, M.S.E., Enrique Lin Shiao, Ph.D. Candidate

Website: www.amsterdamfluidics.com

For Inquiries Please Contact: Niyathi Chakrapani at niyathic@upenn.edu

 


Bonbouton is a technology platform for preventative diabetic health care. Our first product, a smart insole with a proprietary embedded graphene sensing system, passively monitors the skin’s physiological signals in order to detect early signs of foot ulcers. This simplifies patient self-monitoring and reduces the frequency of doctor visits.

Bonbouton is the Smart Clothings winner of Wearable Technology Innovation World Cup 2017, a 1776 Health Fellow (2017), a Next Top Makers Fellow (2016) and a National Science Foundation awardee.

Inventors: Dr. Linh Le, Dr. Malcolm Nason, Mr. Campbell Weaver

Website: http://bonbouton.co/

For Inquiries Please Contact: hello@bonbouton.co

 

Folia Water logo
Folia Water makes the world’s first-ever consumer goods water filter that costs pennies, not dollars. Our patent-pending nanosilver-infused Folia Filter papers are packaged like a coffee filter, retail for only 50 cents, and can provide germ-free water for a week to a family.  Folia Filters are 10X cheaper than bottled water, with a huge market: 3 billion people who currently spend $20B on water.  Our vision is for our Folia Filters to be sold in every store in the developing world. Bread, milk, eggs, Folia Filters: the next $1 billion staple.

  • Founders: McGill chemistry PhD, Columbia env. engineering PhD
  • B2B2C wholesale to emerging market consumer goods distributors

Inventors: Teri Dankovich, Ph.D. & Jonathan Levine, Ph.D.

Website: foliawater.com

For Inquiries Please Contact: Jonathan Levine and Teri Dankovich at info@foliawater.com

 

Therapeutic Articulations logo

Therapeutic Articulations, LLC

Inventors:

Dawn T. Gulick, PhD, PT, AT, CSCS
Therapeutic Articulations, LLC
Founder & CEO

There are millions of musculoskeletal injuries which occur each year resulting in pain, swelling, and limitations in joint movement.  Clinicians routinely use joint mobilizations to address pain and limited mobility related to musculoskeletal injury.  Currently, joint motion of an individual with an orthopedic injury is measured in one of several ways: goniometer, accelerometers, or motion analysis systems.

Mobil-AiderTM represents a “first-to-market” technology for arthrokinematic/linear assessment.  A key innovation is the development of a device to quantify and compartmentalize the magnitude of joint translation. The use of LED feedback will provide appropriately graded and effective treatments across various joints of the body. This technology will ensure that when a patient is treated by different clinicians, a standardized treatment will be rendered. Consistency will enhance the patient outcome with regard to pain reduction and improved joint mobility.

The competitive advantage of the Mobil-AiderTM is that it is small/portable with attachments to conform to the shape of multiple joints.  Also, it will not require any additional training because the techniques used will be the same as those typically rendered in the clinic between the clinician’s hand and patient’s joint.

Website: www.iortho.xyz

For Inquiries Please Contact:
Dawn T Gulick, PhD, PT, AT, CSCS

Website:  www.iortho.xyz

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NanoNeuroScope: wireless, wearable EEG with nanowire sensors

In the last few years, the demand for advanced imaging techniques for brain monitoring has surpassed the available options, which led to the diversification of the EEG devices and growth of its market. However, in spite of this rapid growth and forecasts, there currently aren’t any viable options for a low cost, wireless, research grade EEG device that can be worn for prolonged periods to seamlessly monitor brain states while participants’ engage in real world interactions. NanoNeuroScopes hopes to fill that niche. These sensors can produce high quality signals, but at the same time they don’t require gel and are easy to wear. Vast troves of digital health data can be effectively utilized to develop personalized treatment protocols in medicine and individual customer–based advertisements for marketing. In conjunction with cognitive behavioral tasks, mathematical modeling, eye tracking and pupillometry, we aim to establish sensitive, objective, biomarkers that can vastly improve the quality of life of patients and customer satisfaction in business.

Inventors: Dr. Arjun Ramakrishnan, Dr. Michael Platt, Mr. Miguel Hernandez, Mr. Naz Belkaya, Ms. Dilara Berkay

For Inquiries Please Contact: Dr. Arjun Ramakrishnan at arjunra@mail.med.upenn.edu

 

 

VisiPlate logo
Open angle glaucoma is a condition that can lead to blindness; it currently affects 2.8 million people in the U.S. and incurs societal costs of $1.5 billion per year. Current treatment algorithms have high failure rates and poor patient compliance, so by being a permanent and efficacious medical implant, VisiPlate can improve treatment outcomes for millions of OAG patients.

VisiPlate is the first nanoscale aqueous shunt for OAG patients with a drainage plate located in front of the eye muscles. VisiPlate consists of a drainage tube and a drainage plate comprised of proprietary, ultra-thin plate technology (100nm thickness) developed at the University of Pennsylvania. The thinness of VisiPlate can lead to a 65% smaller drainage pocket (bleb), reducing risk of otherwise common postoperative complications such as patient eye discomfort, double vision, and healthy tissue erosion. Furthermore, proprietary nano-channels allow for better drainage of intraocular fluid, while material flexibility allows conformation to the curvature of the eye.

By combining the golden standard trabeculectomy procedure with unique mechanical characteristics, VisiPlate will reduce procedure time for ophthalmologists as well as improve the postoperative standard of living for patients.

Inventors: Brandon Kao, Adarsh Battu, Rui Jing Jiang

For Inquiries Please Contact:

Brandon Kao bkao@seas.upenn.edu
Adarsh Battu abattu@wharton.upenn.edu
Rui Jing Jiang rjiang@wharton.upenn.edu

 

Sanguis Logo

Sanguis is a smartphone-sized, inexpensive, and rapid neutrophil count monitoring device. Just as a glucometer has revolutionized the lives of the millions of patients with diabetes, Sanguis will do the same for cancer patients and many others. Our vision is that every one of these patients goes home with Sanguis, the world’s most inexpensive and user-friendly blood count monitor, which would prevent life-threatening medical complications arising from dangerously low counts. With Sanguis, we will prevent more than tens of thousands of deaths each year and improve the lives of millions worldwide.

Inventors: Mr. Daniel Zhang, Mr. Divyansh Agarwal, Mr. Prateek Agarwal

Website: http://sanguislab.com

For Inquiries Please Contact: Mr. Divyansh Agarwal at Divyansh.agarwal@uphs.upenn.edu